The field of proteomics has developed rapidly over the past decade, with many new instruments, protocols and biological applications appearing. The informatics aspects of proteomics have evolved at an equally rapid pace, with many new tools, new algorithms, and improvements to best practice being published. Providing a detailed introduction to the main informatics topics that underpin the various LC-MS/MS protocols used for protein identification and quantitation, this book brings together the key proteome informatics methodologies for researchers and practising analytical scientists.