The objective of this book is to present Harm Reduction (DR) from an ethical, aesthetic and political perspective. Thus, this text attempts to make an initial approach to the history of harm reduction, the principles, the characteristics and its main strategies. Situating throughout the text, Harm Reduction as a practice in which the professional can be situated in the ethical, aesthetic, and political register, in order to hear the pain of the other in the register of the human happening. To situate oneself before the complaints of the users, without misrepresenting or reducing them. Harm reduction as a promising way to recognize each user in his uniqueness, drawing with him strategies to promote health and ensure their rights as citizens. Harm reduction as a bet on the human.