This new volume explores the new paradigm that is Industry 4.0--the application of information-intensive technologies that integrate software, hardware, and biology (cyber-physical systems) for effective manufacturing and related industries. This volume focuses specifically on leadership that can respond quickly and effectively to changing conditions in the Industry 4.0 environment. It looks at leadership skills needed during the COVID-19 pandemic, skills that can be applied to many other changing conditions as well. The authors consider the role of virtual leadership in an age of working from home; present case studies that provide valuable lessons for the agile leader; and examine the crucial role of human resources in providing agile leadership to an organization. The volume aggregates original theoretical, conceptual, and empirical research on challenges and opportunities in the context on Industry 4.0.